Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spatial working memory as an endophenotype for schizophrenia.

David C Glahn1, Sebastian Therman, Marko Manninen

  • 1Department of Psychology, University of California Los Angeles, Los Angeles, California, USA.

Biological Psychiatry
|April 8, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural and functional covariance architecture of major depressive disorder: A meta-analytic structural equation modeling approach to primary neuroimaging analysis.

Brain organoid & systems neuroscience journal·2026
Same author

Prefrontal Circuitry Abnormalities and Cognitive Impairment in Adolescents with Early- Onset Psychosis.

Research square·2026
Same author

Neuroimaging Summary Scores Predict Trajectories of Psychotic-Like Experiences in Youth.

medRxiv : the preprint server for health sciences·2026
Same author

Gene × sex interactions on cognition in the Philadelphia neurodevelopmental cohort.

Biology of sex differences·2026
Same author

Brain Morphology Mediators of the Association of Childhood Trauma With Bipolar Disorder: An International ENIGMA Bipolar Disorder Working Group Study.

JAMA psychiatry·2026
Same author

Evaluating psychosis-specific effects of trauma exposure in early-onset and adult-onset psychosis.

Psychological medicine·2026

Spatial working memory deficits, particularly in encoding and storage, may serve as an endophenotypic marker for schizophrenia. This study investigated these memory processes in twins with varying genetic risk for schizophrenia.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Spatial working memory impairments are linked to genetic predisposition for schizophrenia.
  • Previous research showed dose-dependent impairment with genetic loading, but the specific deficit remained unclear.

Purpose of the Study:

  • To investigate specific spatial working memory deficits in individuals with genetic predisposition to schizophrenia.
  • To determine if deficits lie in encoding, maintenance, manipulation, or storage of spatial information.

Main Methods:

  • Developed a spatial delayed response task with varied memory set sizes.
  • Reassessed 80 twins (including monozygotic and dizygotic co-twins) and healthy controls.

Main Results:

Related Experiment Videos

  • The spatial delayed response task identified sensitivity to genetic loading for schizophrenia.
  • No evidence of capacity limitations was found in probands or their co-twins.

    • Conclusions:

    • Deficits in encoding or storage of short-term spatial information may be a viable endophenotypic marker for schizophrenia.
    • This finding aids in understanding the neurocognitive underpinnings of schizophrenia.