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Related Experiment Videos

Local excision carcinoma in early stage.

Ji-Dong Gao1, Yong-Fu Shao, Jian-Jun Bi

  • 1Department of General Surgical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China. ab168@vip.sina.com

World Journal of Gastroenterology
|April 8, 2003
PubMed
Summary

Local excision is a safe and effective treatment for early-stage low rectal cancer, offering a viable alternative to radical resection with minimal complications. This approach shows promising survival rates for patients with T1 and T2 lesions.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Gastrointestinal Surgery

Background:

  • Early-stage low rectal cancer presents treatment challenges.
  • Radical resection is a standard but invasive option.
  • Local excision offers a potentially less morbid alternative.

Purpose of the Study:

  • To evaluate the efficacy and safety of local excision for early-stage low rectal cancer.
  • To compare local excision outcomes with radical resection.
  • To identify factors influencing recurrence and survival after local excision.

Main Methods:

  • Retrospective review of 47 patients with early-stage low rectal cancer treated with local excision (transanal, trans-sacral, or trans-vaginal) between 1980-1999.
  • Analysis of tumor characteristics (T1/T2), surgical margins, postoperative radiotherapy, local recurrence, and survival rates.

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  • Statistical analysis to determine factors associated with recurrence and survival.

    • Main Results:

    • Local excision was performed with no surgical mortality.
    • The 5-year survival rate was 91.7% (94.4% for T1, 83.3% for T2).
    • Local recurrence occurred in 14.9% of patients; positive margins were associated with recurrence.

    Conclusions:

    • Local tumor excision is a safe procedure for early-stage low rectal cancer.
    • It offers minimal morbidity and mortality.
    • Local excision can be considered a primary surgical treatment option for this condition.