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[Estrogen and bone metabolism in man].
Wei-Dong Gan1, Yu-Tian Dai, Ze-Yu Sun
1Department of Urology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, Nanjing, Jiangsu 210008, China.
Zhonghua Nan Ke Xue = National Journal of Andrology
|April 12, 2003
Summary
Estrogen plays a crucial role in male bone health, influencing bone growth and mass. Estrogen deficiency or estrogen receptor gene mutations in males can result in osteopenia and osteoporosis.
Area of Science:
- Endocrinology
- Bone Biology
- Reproductive Biology
Context:
- Androgens are converted to estrogens in males via aromatase.
- Estrogen receptors are present in male human osteoblasts.
- Bone is a significant target tissue for estrogen in males.
Purpose:
- To highlight the critical role of estrogen in male bone health.
- To underscore the consequences of estrogen deficiency or receptor dysfunction in males.
Summary:
- Estrogen is essential for male bone development during puberty and for maintaining bone mass throughout life.
- Estrogen deficiency or estrogen receptor gene mutations in males are linked to reduced bone density, leading to osteopenia and osteoporosis.
Impact:
- This research emphasizes the importance of estrogen signaling for skeletal integrity in males.
- Findings suggest potential therapeutic targets for male osteoporosis related to estrogen pathways.