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[Vaccinations and solid-organ transplantation: review and recommendations]
J Iglesias Berengue1, J López Espinosa, M Campins Martí
1Equipo de Trasplante Hepático Pediátrico. Hospital Universitario Vall d'Hebron. Barcelona. España. jiglesias.hmi@cs.vhebron.es
Insights
Pediatric solid-organ transplant recipients need careful immunization monitoring. This review covers vaccine safety and strategies to prevent infectious diseases in these vulnerable children.
Area of Science:
- Immunology
- Pediatric Infectious Diseases
- Transplantation
Context:
- Pediatric solid-organ transplant (SOT) recipients face heightened risks of infectious diseases.
- Many pediatric patients are not fully vaccinated prior to SOT.
- Lack of consensus exists regarding optimal immunization schedules for SOT recipients.
Purpose:
- To review current data on vaccine safety and efficacy in pediatric SOT recipients.
- To outline strategies for preventing vaccine-preventable diseases in this population.
- To address the need for standardized immunization guidelines.
Summary:
- This review synthesizes available evidence on the safety and effectiveness of vaccines in children undergoing solid-organ transplantation.
- It highlights the critical importance of monitoring immunization status and implementing appropriate vaccination schedules.
- Strategies are discussed to mitigate the risk of serious infections post-transplant.
Impact:
- Informing clinical practice for physicians managing pediatric SOT recipients.
- Improving long-term health outcomes by reducing vaccine-preventable disease burden.
- Guiding the development of evidence-based immunization guidelines for immunocompromised children.
Abstract:
Pediatric solid-organ transplant recipients are at high risk for various infectious diseases. Many children are not fully vaccinated before transplantation. To reduce the risk of morbidity and mortality from vaccine-preventable disease, physicians treating pediatric solid-organ transplant recipients should monitor the immunization status of these patients. Consensus on the most appropriate immunization schedule for solid-organ transplant recipients is lacking. Therefore, we provide a review of the currently available data on immunization safety and efficacy and describe strategies to avoid vaccine-preventable diseases in pediatric solid-organ transplant recipients.