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Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
Published on: March 17, 2014
Chronic lung sepsis: lung abscess, bronchiectasis, and empyema
Naresh G Mansharamani1, Henry Koziel
1Attending/Consultant Physician, Newport Hospital, Rhode Island, USA. NARESH3@aol.com
Abstract:
Chronic lung infections including lung abscess, bronchiectasis, and empyema remain serious medical diseases despite the availability of antimicrobial agents. Recent publications contribute to our understanding of disease pathogenesis and management of these entities. The microbial pathogen of lung abscess may be different comparing immunocompetent with immunocompromised patients, supporting a concept for aggressive diagnostic investigations and targeting of specific potential pathogens. The use of surgery in bronchiectasis may be declining, but surgical intervention remains an important strategy with favorable outcomes, especially in cases of focal bronchiectasis. For empyema, maintaining a high index of clinical suspicion may allow for diagnostic thoracentesis in patients with pleural effusions and allow initiation of appropriate tube thoracotomy drainage and use of fibrinolytics. With appropriate management, morbidity and mortality may be limited and outcomes generally favorable.
Insights
Chronic lung infections like lung abscess, bronchiectasis, and empyema require specific management. Early diagnosis and targeted treatments, including surgery for focal bronchiectasis and drainage for empyema, improve patient outcomes.
Area of Science:
- Pulmonology
- Infectious Diseases
- Thoracic Surgery
Background:
- Chronic lung infections, including lung abscess, bronchiectasis, and empyema, persist as significant health concerns despite antimicrobial availability.
- Understanding the pathogenesis and management of these conditions is crucial for effective treatment.
Purpose of the Study:
- To review recent advancements in the understanding and management of chronic lung infections.
- To highlight the importance of tailored diagnostic and therapeutic strategies for lung abscess, bronchiectasis, and empyema.
Main Methods:
- Review of recent publications on the pathogenesis and management of chronic lung infections.
- Analysis of diagnostic approaches and treatment strategies for lung abscess, bronchiectasis, and empyema.
Main Results:
- Lung abscess pathogens may differ between immunocompetent and immunocompromised individuals, necessitating targeted investigations.
- Surgical intervention for bronchiectasis, particularly focal cases, remains effective despite declining use.
- Early suspicion and intervention for empyema, including thoracentesis and drainage, are key to favorable outcomes.
Conclusions:
- Appropriate management, including specific diagnostics and interventions, can limit morbidity and mortality associated with chronic lung infections.
- Outcomes for lung abscess, bronchiectasis, and empyema are generally favorable with timely and targeted treatment strategies.
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