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[Neuroprotective properties of pyroglutamic acid in combination with pyrrolidone]
E V Lun'shina1, T S Gan'shina, L M Makarova
1Laboratory of Pharmacology of Cerebrovascular Disorders, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya Str. 8, Moscow, 125315, Russia.
Abstract:
A new drug composition containing pyroglutamic acid and pyrrolidone produces a significant effect on the cerebral circulation in rats with global recurrent brain ischemia and in a model ischemic state under high radial gravitational overload. In the former case, the new drug increases the blood circulation in rats with the global ischemic damage to a greater extent than in the intact control group. Pretreatment with the pyroglutamic acid--pyrrolidone composition produced a 2-2.5-fold increase in the survival of rats in the ischemic state caused by the radial gravitational overload. The data obtained show evidence of a substantial neuroprotector action of the new drug composition.