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[Hemorheological effects of polyethylene oxide in rats with acute myocardial ischemia]
M B Plotnikov1, G A Chernysheva, M S Nevzorov
1Institute of Pharmacology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, pr. Lenina 3, Tomsk, 634028 Russia.
Abstract:
The effect of polyetox, a medicinal form of high-molecular-weight poly(ethylene oxide) (HMWPEO) on the rheological properties of blood and the necrotic zone size was studied in rats with an acute myocardial ischemia model (on the 5th day after coronary artery occlusion). The drug was infused intravenously in a single daily dose over a period of three days, which resulted in a final HMWPEO concentration of 1 x 10(-6) g/ml in the blood. The first treatment was carried out 1 h after coronary artery occlusion. Animals in the cotrol group with myocardial infarction exhibited high blood viscosity syndrome with stable decrease in the hydrodynamic index. The administration of polyetox reduced blood viscosity, decreased the erythrocyte aggregation, and increased the antiturbulent properties (hydrodynamic index) of the blood. The myocardial infarction zone decreased by 38%, which was manifested in improved EEG parameters.
Insights
Polyetox, a high-molecular-weight poly(ethylene oxide) (HMWPEO) formulation, improved blood flow and reduced heart damage in a rat myocardial infarction model. This study highlights its potential for treating ischemic heart conditions.
Area of Science:
- Cardiovascular Science
- Pharmacology
- Biomedical Engineering
Background:
- Acute myocardial infarction leads to high blood viscosity syndrome.
- Impaired rheological properties and reduced hydrodynamic index are characteristic of myocardial infarction.
Purpose of the Study:
- To investigate the effects of polyetox (HMWPEO) on blood rheology and infarct size in a rat model of acute myocardial ischemia.
- To assess the therapeutic potential of HMWPEO in improving blood flow dynamics and reducing cardiac necrosis.
Main Methods:
- Rats with myocardial infarction were treated with polyetox intravenously over three days.
- Blood viscosity, erythrocyte aggregation, and hydrodynamic index were measured.
- Necrotic zone size and EEG parameters were evaluated to assess infarct size and cardiac function.
Main Results:
- Polyetox administration significantly reduced blood viscosity and erythrocyte aggregation.
- The antiturbulent properties of blood, indicated by the hydrodynamic index, were enhanced.
- A 38% reduction in the myocardial infarction zone was observed, accompanied by improved EEG parameters.
Conclusions:
- Polyetox effectively improves blood rheological properties in the context of myocardial ischemia.
- HMWPEO demonstrates a significant cardioprotective effect by reducing infarct size.
- These findings suggest polyetox as a promising therapeutic agent for managing acute myocardial infarction.