Electrochemical analysis and analgesic behavior of Zn(II)-baclofen complex

The electroanalytical behavior of Zn(II)-baclofen complex has been described by direct current polarographic (DCP) method. The complex of transition metal Zn(II) with baclofen, [4-amino-3(4-chlorophenyl) butanoic acid, has been prepared and characterized on the basis of elemental analysis, IR-spectral, polarographic and amperometric studies. The metal-ligand interaction in aqueous medium has been studied polarographically at 25 degrees C and at an ionic strength of mu = 1.0 M KCl. The reduction of the complex was found to involve two electrons and of diffusion controlled nature. The analytical results indicated a 1:1 (M:L) stoichiometry for Zn(II)-baclofen complex. The results on the drug and drug-metal complex revealed that the complex is more potent as compared with the parent drug.