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Related Experiment Videos

Spinal cats on the treadmill: changes in load pathways.

Marie-Pascale Côté1, Ariane Ménard, Jean-Pierre Gossard

  • 1Centre de Recherche en Sciences Neurologiques, Département de Physiologie, Faculté de Médecine, Université de Montréal, Montréal, Québec, Canada H3C 3J7.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|April 10, 2003
PubMed
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Treadmill training improves spinal cord function by reducing monosynaptic excitation and enhancing clonidine

Area of Science:

  • Neuroscience
  • Motor Control
  • Spinal Cord Injury Research

Background:

  • Spinal cord injury (SCI) impairs locomotion.
  • Treadmill training and clonidine show promise in restoring hindlimb function after SCI.
  • Load-bearing pathways are crucial for body support during locomotion.

Purpose of the Study:

  • To investigate the specific effects of treadmill training on group I pathways involved in load transmission.
  • To determine how clonidine interacts with these pathways in trained versus untrained spinal cats.

Main Methods:

  • Comparison of two groups of spinal cats: trained (n=11) and untrained (shams, n=7).
  • Acute electrophysiological experiments measuring responses in extensor motoneurons before and after clonidine administration.

Related Experiment Videos

  • Analysis of monosynaptic, disynaptic, and polysynaptic group I pathways, including fictive stepping.

    • Main Results:

    • Treadmill training significantly decreased monosynaptic excitation.
    • Clonidine reduced disynaptic inhibition more effectively in trained cats.
    • Clonidine more frequently reversed group IB inhibition to polysynaptic excitation in trained cats.
    • Phase-dependent modulation of neuronal responses during fictive stepping was altered in trained cats.

    Conclusions:

    • Treadmill training modifies spinal circuits to enhance recovery of locomotion after SCI.
    • Training enhances the beneficial effects of clonidine, promoting disinhibition and excitatory pathway recruitment.
    • These adaptations facilitate extensor muscle activation for weight-bearing during stepping.