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Updated: Feb 12, 2026

Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase
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Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase

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Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

Ming-Tain Lai1, Elizabeth Chen, Ming-Chih Crouthamel

  • 1Department of Biological Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA. mingtain_lai@merck.com

The Journal of Biological Chemistry
|April 10, 2003
PubMed

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