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Updated: Sep 26, 2026

Spatial Separation of Molecular Conformers and Clusters
Published on: January 9, 2014
Electrophoretic enantiomer separations at high pH using the new, single-isomer
M Brent Busby1, Omar Maldonado, Gyula Vigh
1Department of Chemistry, Texas A&M University, College Station, TX 77842-3012, USA.
Abstract:
The latest, single-isomer, sulfated gamma-cyclodextrin, the sodium salt of octakis(2,3-dimethyl-6-O-sulfo)-gamma-cyclodextrin that is stable in basic media was used to separate the enantiomers of neutral, weak acid and weak base analytes by capillary electrophoresis in high pH aqueous background electrolytes. The effective mobilities and separation selectivities were found to follow trends similar to those observed earlier in acidic aqueous background electrolytes. Octakis(2,3-dimethyl-6-O-sulfo)-gamma-cyclodextrin proved to interact with all three analyte types less strongly than other single-isomer sulfated cyclodextrins do under comparable conditions.
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