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Synthesis and anticancer activity of 5'-phthaloylnucleosides
1Institute of Chemistry, Agricultural University, Warsaw, Poland. orzeszkoa@delta.sggw.waw.pl
Die Pharmazie
|April 11, 2003
Abstract:
A series of novel 5'-phthaloylnucleosides were synthesized via Mitsunobu reaction starting from AZT or 2'-deoxyadenosine and numerous phthalimides and their sulphur analogues-thioimides. Some of them showed significant anticancer activity.