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B-cell lymphoma mimicking multiple myeloma.
Nauman Moazzam1, Azhar A Malik, Anil Potti
1Department of Internal Medicine, University of North Dakota School of Medicine, MeritCare Medical Center (170), 720 North 4th street, Fargo, ND 58102, USA. nauman_pirzada@hotmail.com
Leukemia & Lymphoma
|April 11, 2003
Summary
This case highlights B-cell lymphoma presenting with hypercalcemia, renal failure, and bone lesions, mimicking multiple myeloma. Early diagnosis is crucial for effective B-cell lymphoma treatment.
Area of Science:
- Oncology
- Hematology
Background:
- Multiple myeloma is a plasma cell malignancy characterized by bone lesions, hypercalcemia, and renal failure.
- B-cell lymphomas are a diverse group of lymphoid neoplasms.
Observation:
- A 75-year-old male presented with shoulder pain, hypercalcemia, and multiple lytic bone lesions.
- Imaging revealed a renal mass and liver lesions. Bone marrow biopsy was negative for plasma cell dyscrasia.
Findings:
- Liver biopsy confirmed B-cell lymphoma, with cells positive for CD19 and CD20.
- The clinical presentation mimicked multiple myeloma.
Implications:
- B-cell lymphomas can present atypically, mimicking other hematologic malignancies like multiple myeloma.
- This case underscores the importance of comprehensive diagnostic workups for patients with unexplained hypercalcemia and bone lesions.