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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Origin of a central nervous system lymphoid neoplasm in an immunocompromised host with acute lymphoblastic leukemia
Sharon P Mayer1, Somasundaram Jayabose, Oya Tugal
1Department of Pediatric Hematology-Oncology, New York Medical College, Munger Pavillion, Rm 110, Valhalla, NY 10595, USA.
Abstract:
We describe a case of relapsed pediatric pre-B acute lymphoblastic leukemia (ALL) with a simultaneous presentation of an intracerebral lymphoid mass. Cytogenetic, immunophenotypic and molecular analysis (immunoglobulin heavy chain and T-cell receptor gene rearrangements) revealed that the brain neoplasm was distinct from the relapsed leukemia. We discuss the etiology of this extremely rare event, and raise issues about the clonality of lymphoid neoplasms and the behavior of hematopoietic cells within the central nervous system (CNS).
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