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Published on: February 21, 2018
Granular B-acute Lymphoblastic Leukemia with BCR::ABL1 Fusion Mimicking Acute Promyelocytic Leukemia
1Department of Clinical Laboratory, The First Hospital of Qinhuangdao, No. 258 Wenhua Road, Qinhuangdao, 066000 China.
Abstract:
A case of BCR::ABL1-positive B-cell acute lymphoblastic leukemia (B-ALL) initially mimicked acute promyelocytic leukemia (APL) due to blast cells with abundant azurophilic granules. However, the diagnosis was corrected by negative myeloperoxidase (MPO) staining, a B-cell immunophenotype, and genetic studies. This highlights the importance of integrated diagnostics in differentiating granular B-ALL from APL.