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Genetically mediated brain abnormalities in schizophrenia.

Larry J Seidman1, Heidi E Wencel

  • 1Neuropsychology Laboratory, Massachusetts Mental Health Center, 74 Fenwood Road, Boston, MA 02115, USA. larry_seidman@hms.harvard.edu

Current Psychiatry Reports
|April 11, 2003
PubMed
Summary
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Schizophrenia genetics are complex, with linkage findings on multiple chromosomes. Neuroimaging in relatives reveals potential vulnerability markers, aiding in understanding the disorder's pathophysiology.

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Schizophrenia is a highly heritable neurobehavioral disorder with complex inheritance patterns.
  • Previous linkage studies have yielded inconsistent findings, though some chromosomal regions (1, 6, 8, 11, 13, 15, 22) show promise.

Purpose of the Study:

  • To explore new methods for identifying candidate genes in schizophrenia.
  • To investigate neurobiologic phenotypes in relatives as potential vulnerability markers.
  • To advance the understanding of schizophrenia's pathophysiology by linking genes to brain regions.

Main Methods:

  • Utilizing neurobiologic phenotypes observed in relatives of individuals with schizophrenia.
  • Conducting neuroimaging studies to assess brain structure and function in relatives.

Related Experiment Videos

  • Examining candidate genes such as catechol-O-methyltransferase and serotonin receptor transporter.

    • Main Results:

    • Neuroimaging suggests mild variants of hippocampal and prefrontal network abnormalities in relatives, potentially indicating vulnerability.
    • Evidence points to a minor role for the catechol-O-methyltransferase gene (22q) and serotonin receptor transporter gene (17q11-q12) in schizophrenia development.

    Conclusions:

    • Neurobiologic phenotypes in relatives may serve as stable vulnerability markers for schizophrenia, unaffected by medication or psychosis.
    • Identifying specific genes and their association with brain regions/networks is crucial for elucidating schizophrenia's underlying mechanisms.