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An Introduction to the Human Connectome Project for Early Psychosis.

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The Human Connectome Project for Early Psychosis (HCP-EP) offers a valuable dataset for studying early psychosis. This publicly available data aids researchers in understanding brain connections and developing interventions for psychosis.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Brain Imaging

Background:

  • The period after psychosis onset is crucial for effective intervention.
  • Studying early psychosis aids in identifying brain biomarkers before long-term effects.
  • The Human Connectome Project for Early Psychosis (HCP-EP) extends the original HCP's brain connectivity research.

Purpose of the Study:

  • To provide an overview of HCP-EP procedures, assessments, and protocols.
  • To characterize the study participants for easier dataset utilization.
  • To facilitate research on early psychosis by making data publicly available.

Main Methods:

  • Data collected across multiple sites in Massachusetts and Indiana.
  • Brigham and Women's Hospital served as the data coordination center and imaging site.
  • Utilized the Human Connectome Project's approach to brain connectivity.

Main Results:

  • Acquired high-quality clinical, cognitive, functional, neuroimaging, and blood data from 303 individuals (ages 16-35).
  • Included participants with affective psychosis (n=75), non-affective psychosis (n=148), and healthy controls (n=80).
  • Participants with early psychosis were within 5 years of illness onset (mean 1.9 years).

Conclusions:

  • The HCP-EP dataset is publicly available for the research community.
  • The study provides a rich dataset for investigating early psychosis.
  • Researchers can utilize the data to group participants in various ways for diverse analyses.