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Familial vesicoureteral reflux.

Boris Chertin1, Prem Puri

  • 1Children's Research Centre, Our Lady's Hospital for Sick Children, University College Dublin, Dublin, Ireland.

The Journal of Urology
|April 11, 2003
PubMed
Summary
This summary is machine-generated.

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Siblings of children with vesicoureteral reflux (VUR) have a significantly higher incidence of this condition. Early screening of asymptomatic siblings is recommended to detect VUR and prevent potential kidney damage.

Area of Science:

  • Pediatric Nephrology
  • Urology
  • Genetics

Background:

  • Vesicoureteral reflux (VUR) demonstrates familial aggregation.
  • Understanding the incidence and characteristics of VUR in siblings is crucial for early diagnosis and management.

Purpose of the Study:

  • To summarize global data on the incidence and nature of VUR in siblings of affected children.
  • To assess the risk of renal damage in siblings with VUR.

Main Methods:

  • Systematic literature search of MEDLINE (1972-2002) using keywords related to VUR in siblings and family.
  • Analysis of identified articles for the incidence of VUR and renal damage in siblings.

Main Results:

  • Siblings of VUR patients exhibit a substantially higher reflux incidence compared to the general population.

Related Experiment Videos

  • Reflux incidence and severity correlate directly with patient age.
  • Screening of asymptomatic siblings is widely advocated.

    • Conclusions:

    • Sibling VUR incidence is significant, often presenting as high-grade reflux with associated reflux nephropathy in symptomatic cases.
    • Further randomized controlled trials are needed to evaluate the effectiveness of screening in preventing renal damage in asymptomatic siblings compared to diagnosis post-urinary tract infection.