Effect of Immune Interactions in Mother-Fetus System on Formation of Immune Response to Main Vaccinal Antigens

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Published on: March 25, 2016

Andrey V. Shabaldin1, Andrey N. Glushkov, Viktor V. Raikhel

  • 1Kemerovo Scientific Center, Siberian Branch of Russian Academy of Sciences, Kemerovo, Russia.

Russian Journal of Immunology : RJI : Official Journal of Russian Society of Immunology
|April 11, 2003
PubMed

Insights

Maternal immune disturbances can impact a child's immune response to vaccines. A study found a link between parental immune issues and lower response to diphtheria vaccines in children, but not measles vaccines.

Area of Science:

  • Immunology
  • Vaccinology
  • Reproductive Immunology

Background:

  • Immune disturbances during pregnancy can persist postnatally, leading to immune pathologies.
  • The impact of these maternal-fetal immune disturbances on a child's vaccine response is not fully understood.

Purpose of the Study:

  • To investigate the relationship between maternal-fetal immune disturbances and the postvaccinal immune response in children.
  • To determine if parental immune system indicators can predict vaccine efficacy.

Main Methods:

  • Studied 81 children aged 14 months for immune response to diphtheria and measles antigens using passive hemagglutination.
  • Assessed parental immune disturbances via mixed lymphocyte culture (MLC) and determination of blocking activity of female serum (BAS) in MLC.

Main Results:

  • A weak parental MLC response combined with absent BAS was associated with a diminished immune response to diphtheria antigen in children.
  • No significant correlation was found between the strength of immune response to measles vaccine and parental immune reproductive disturbances.

Conclusions:

  • Parental immune status, particularly concerning MLC and BAS, may help predict the efficacy of diphtheria-related vaccines (DTP, DT).
  • Further research is needed to understand the complex interplay between maternal-fetal immunity and vaccine responses, especially for measles vaccines.

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