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Anti-angiogenic agents for the treatment of brain tumors

Michael J Fisher1, Peter C Adamson

  • 1Division of Oncology, Children's Hospital of Philadelphia, ARC 907B, 3615 Civic Center Boulevard, Philadelphia, PA 19104-4399, USA.

Neuroimaging Clinics of North America
|April 12, 2003
PubMed

Insights

Novel antiangiogenic agents show promise for treating malignant brain tumors. Advanced neuroimaging will aid in developing these therapies by evaluating tumor vascularity and treatment response.

Area of Science:

  • Oncology
  • Neuroscience
  • Medical Imaging

Background:

  • Malignant brain tumors often require novel therapeutic strategies.
  • Tumor vascularity suggests potential for antiangiogenic therapies.
  • Preclinical studies support the use of antiangiogenic agents.

Purpose of the Study:

  • To explore the potential of antiangiogenic agents in brain tumor treatment.
  • To highlight the role of understanding angiogenesis in developing targeted therapies.
  • To emphasize the importance of neuroimaging in evaluating antiangiogenic treatments.

Main Methods:

  • Review of current understanding of angiogenesis in brain tumors.
  • Analysis of preclinical data on antiangiogenic agents.
  • Discussion of neuroimaging techniques for assessing tumor vasculature and treatment efficacy.

Main Results:

  • Antiangiogenic agents show promise as part of multimodal brain tumor therapy.
  • Improved understanding of angiogenesis biology allows for targeted vascular strategies.
  • Neuroimaging is crucial for evaluating the impact of these novel agents.

Conclusions:

  • Antiangiogenic therapy represents a potential advancement in brain tumor treatment.
  • Targeted vascular strategies informed by angiogenesis research are promising.
  • Neuroimaging is essential for the clinical development and application of antiangiogenic agents.

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