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Pattern formation inside bacteria: fluctuations due to the low copy number of proteins
Martin Howard1, Andrew D Rutenberg
1Instituut-Lorentz, Leiden University, P.O. Box 9506, 2300 RA Leiden, The Netherlands.
Physical Review Letters
|April 12, 2003
Abstract:
We examine fluctuation effects due to the low copy number of proteins involved in pattern-forming dynamics within a bacterium. We focus on a stochastic model of the oscillating MinCDE protein system regulating accurate cell division in E. coli. We find that, for some parameter regions, the protein concentrations are low enough that fluctuations are essential for the generation of patterns. We also examine the role of fluctuations in constraining protein concentration levels.