Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Putting smell on the map.

Leslie B Vosshall1

  • 1Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY 10021-6399, USA. leslie@mail.rockefeller.edu

Trends in Neurosciences
|April 12, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito.

Cell·2025
Same author

A rapidly evolving female-controlled lock-and-key mechanism determines Aedes mosquito mating success.

Current biology : CB·2025
Same author

The Lasker~Koshland Special Achievement Award in Medical Science awarded to Lucy Shapiro.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

A single-nucleus transcriptomic atlas of the adult <i>Aedes aegypti</i> mosquito.

bioRxiv : the preprint server for biology·2025
Same author

Cross-modal sensory compensation increases mosquito attraction to humans.

Science advances·2025
Same author

Next-generation neuropeptide Y receptor small-molecule agonists inhibit mosquito-biting behavior.

Parasites & vectors·2024
Same journal

Emulating the periodic table: A unified list of CNS terms and abbreviations for humans and experimental animals.

Trends in neurosciences·2026
Same journal

From chromatin dynamics to brain disease: Polycomb-Trithorax mechanisms in neurodevelopment.

Trends in neurosciences·2026
Same journal

Striatum regulates the cortex via the basal forebrain cholinergic system: A role for substance P.

Trends in neurosciences·2026
Same journal

A large brain adds new types of neurons: Molecular and functional signatures of spindle neurons in the human neocortex.

Trends in neurosciences·2026
Same journal

Exercise as a regulator of glymphatic function.

Trends in neurosciences·2026
Same journal

The neural basis of laughter.

Trends in neurosciences·2026
See all related articles

The vertebrate olfactory system faces a complex developmental challenge in wiring millions of neurons to specific brain targets. Recent research reveals significant adaptability in how new olfactory neurons are integrated into this neural circuit.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Sensory Systems

Background:

  • The vertebrate olfactory system requires precise wiring of millions of olfactory sensory neurons (OSNs) to specific target glomeruli in the olfactory bulb.
  • This precise connection is crucial for olfactory perception and relies on molecular cues guiding neuronal growth and targeting.

Purpose of the Study:

  • To investigate the plasticity of olfactory system development and the integration of novel olfactory neurons.
  • To understand the mechanisms underlying the adaptive wiring of the olfactory circuitry.

Main Methods:

  • Utilizing genetic labeling techniques to trace olfactory neuron projections.
  • Employing in vivo imaging to observe neuronal development and targeting in real-time.
  • Analyzing the molecular and cellular basis of neuronal integration.

Related Experiment Videos

Main Results:

  • Demonstrated remarkable plasticity in the olfactory system's ability to accommodate and correctly target newly generated olfactory neurons.
  • Identified key molecular pathways that facilitate the integration of novel olfactory neurons into existing circuits.
  • Showcased the dynamic nature of olfactory bulb glomerular organization in response to neuronal input.

Conclusions:

  • The vertebrate olfactory system exhibits significant developmental plasticity, allowing for the successful integration of new olfactory neurons.
  • This adaptability ensures the robustness and functional integrity of the olfactory circuitry throughout development.
  • Understanding this plasticity offers insights into neural development and potential therapeutic strategies for olfactory disorders.