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[Amyloidosis and oxidative stress].

Masaaki Nakamura1, Yukio Ando

  • 1Department of Laboratory Medicine, Kumamoto University School of Medicine, Kumamoto 860-0811.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|April 15, 2003
PubMed
Summary

Oxidative stress contributes to amyloidosis, including dialysis-related amyloidosis (DRA) and familial amyloidotic polyneuropathy (FAP). Radical scavenger therapy showed potential for improving nutritional status in FAP patients.

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Area of Science:

  • Biochemistry
  • Pathology
  • Medical Genetics

Background:

  • Oxidative stress and free radical injury are implicated in amyloid formation and modification.
  • Dialysis-related amyloidosis (DRA) and familial amyloidotic polyneuropathy (FAP) are types of amyloidosis where oxidative stress may play a role.

Purpose of the Study:

  • To investigate the role of oxidative stress in the pathogenesis of DRA and FAP.
  • To propose and evaluate radical scavenger therapy for these amyloidosis conditions.

Main Methods:

  • Examined the association between EC-SOD Arg213Gly polymorphism and disease progression in hemodialysis patients and FAP patients.
  • Conducted histological and biochemical analyses to assess oxidative stress in FAP.
  • Administered radical scavenger therapy (N-acetyl cysteine, vitamin E, vitamin C) to 20 FAP patients for 6 months.

Main Results:

  • EC-SOD Arg213Gly was identified as a risk factor for DRA progression, atherosclerosis, and renal failure.
  • Significant amyloid deposition, potentially linked to oxidative stress, was observed in FAP patients with the EC-SOD Arg213Gly polymorphism.
  • No reduction in amyloid deposition was noted post-therapy, but a trend towards increased modified body mass index (mBMI) was observed.

Conclusions:

  • Oxidative stress is closely linked to the mechanisms of amyloid formation in FAP.
  • Radical scavenger therapy may offer therapeutic potential for amyloidosis, particularly in improving nutritional status.

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