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Updated: Jul 27, 2026
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Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
Published on: June 26, 2020
Neurologic complications of hematologic neoplasms
Lawrence Recht1, Maciej Mrugala
1Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. Lawrence.Recht@umassmed.edu
Neurologic Clinics
|April 15, 2003
Summary
The updated WHO classification aids in understanding neurologic complications from blood cancers like leukemia and lymphoma. It covers direct tumor effects and indirect issues such as infections and vascular problems.
Area of Science:
- Hematology
- Neurology
- Oncology
- Genetics
Background:
- The World Health Organization (WHO) classification of hematopoietic and lymphatic neoplasms has been updated.
- This classification integrates histopathologic, clinical, and genetic data.
- Neurologic complications represent a significant aspect of these neoplasms.
Purpose of the Study:
- To consolidate the understanding of neurologic complications arising from leukemias, lymphomas, and plasma cell dyscrasias.
- To provide a framework for evaluating nervous system involvement in these cancers.
- To highlight the diverse mechanisms underlying these neurologic issues.
Main Methods:
- Review of existing literature and classification systems.
- Analysis of direct and indirect mechanisms of nervous system involvement.
- Categorization of neurologic complications based on etiology.
Main Results:
- Neurologic complications stem from direct tumor infiltration or compression of neural tissues.
- Indirect causes include infections, vascular disorders, iatrogenic effects, and paraneoplastic syndromes.
- The new WHO classification provides a basis for a unified approach to these complications.
Conclusions:
- The updated WHO classification facilitates a comprehensive understanding of neurologic complications in hematopoietic and lymphatic neoplasms.
- Recognizing both direct and indirect mechanisms is crucial for effective patient management.
- This integrated approach benefits pathologists, oncologists, and neurologists.
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