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Updated: Dec 26, 2025

Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System
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Antigen-specific T cells for the treatment of infections after transplantation

Hermann Einsele1

  • 1Medizinische Klinik und Poliklinik, Abteilung II, Eberhard-Karls-Universität Tübingen, Germany. hermann.einsele@med.uni-tuebingen.de

The Hematology Journal : the Official Journal of the European Haematology Association
|April 15, 2003
PubMed

Considerable progress has been made in our understanding of the immunobiology of infections in immunocompromised hosts. Insights derived from animal model and human studies have provided the rationale for investigating immunotherapy with alphabeta+ T cells to restore responses considered essential for protective immunity to cytomegalovirus and Epstein-Barr virus. Future studies will address the role of adoptive immunotherapy in the prevention and treatment of adenovirus and invasive fungal infection. The use of genetically modified T cells has already been evaluated clinically and offers the potential for improving safety and efficacy and removing obstacles to successful immunotherapy. Although these studies are in the early stages and present considerable technical challenges, the results suggest that cellular immunotherapy will be a fruitful area for investigation in future years.

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