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Will endothelin receptor antagonists have a role in heart failure?
Lukas E Spieker1, Thomas F Lüscher
1Cardiovascular Center, University Hospital, Zürich, Switzerland.
The Medical Clinics of North America
|April 16, 2003
Abstract:
Mixed ET(A/B) and selective ET(A) receptor antagonists showed promising hemodynamic and symptomatic improvements in patients with heart failure. Randomized, clinical trials to investigate the effects of ET receptor antagonists on survival in patients with heart failure still need to be conducted. Also, the effects of selective ET(A) and mixed ET(A/B) receptor antagonists on the clinical outcome of patients with CHF will have to be assessed.