Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Is PPD a useful screening agent?

A K Koopmans1, D P Bruynzeel

  • 1Department of Occupational Dermatology, Free University Medical Centre, Amsterdam, the Netherlands.

Contact Dermatitis
|April 16, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diurnal volume changes of the lower legs in healthy males with a profession that requires standing.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2016
Same author

Skin diseases in Europe. Prevention and rehabilitation.

European journal of dermatology : EJD·2009
Same author

Routine patch testing with the preservative system Kathon CG.

International journal of cosmetic science·2009
Same author

Letter to the editor.

International journal of cosmetic science·2009
Same author

Contact dermatitis due to Paeonia (peony): a rare sensitizer?

Contact dermatitis·2009
Same author

Notification of occupational skin diseases by dermatologists in The Netherlands.

Occupational medicine (Oxford, England)·2008
Same journal

Contact Allergy and Allergic Contact Dermatitis From Propylene Glycol and Related Glycols: Cosmetic Skin Sensitisers After All?

Contact dermatitis·2026
Same journal

Acrylate Copolymers/Crosspolymers in Sunscreens: Minimally Allergenic, Without Evidence of Need for Avoidance by (Meth)Acrylate-Sensitized Individuals.

Contact dermatitis·2026
Same journal

AI-Assisted Automated Two-Stage Patch Test Interpretation System Using Vision Transformer.

Contact dermatitis·2026
Same journal

Use of Tralokinumab in a Hairdresser With Severe Chronic Hand Eczema and Occupational Allergic Contact Dermatitis.

Contact dermatitis·2026
Same journal

Occupational Allergic Contact Dermatitis Caused by Cyclohexyl Diethanolamine in a Metalworking Fluid.

Contact dermatitis·2026
Same journal

Fragrance and Preservative Contact Allergens in Cosmetic and Household Cleaning Products in Turkey: Variation by Target Population, Product Type and Manufacturing Origin.

Contact dermatitis·2026
See all related articles

Para-phenylenediamine (PPD) is a useful marker for identifying contact allergy to hair dyes and para-compounds. However, it is not a reliable indicator for sensitivity to disperse dyes, according to this study.

Area of Science:

  • Dermatology
  • Allergology
  • Toxicology

Background:

  • Contact allergy to dyes is a significant concern.
  • Para-phenylenediamine (PPD) is a common allergen found in hair dyes.
  • Assessing cross-reactivity to other para-compounds and disperse dyes is crucial.

Purpose of the Study:

  • To evaluate para-phenylenediamine (PPD) as a screening marker for contact allergy.
  • To investigate the correlation between PPD allergy and reactions to para-compounds and disperse dyes.
  • To determine the relevance of late patch test readings.

Main Methods:

  • Patch testing of 610 patients with PPD, para-compounds, and disperse dyes.
  • Inclusion of patients with known PPD reactions and suspected dye allergies.

Related Experiment Videos

  • Late readings (day 6 or 7) were incorporated to assess delayed reactions.

    • Main Results:

    • Positive reactions to PPD correlated with para-compounds (p-aminoazobenzene, p-toluenediamine sulphate).
    • No significant correlation was found between PPD and disperse dye reactions.
    • Disperse Blue (106, 124) and Disperse Orange (1, 3) were the most frequent disperse dye allergens.
    • Late readings identified 17/24 relevant delayed reactions.

    Conclusions:

    • Para-phenylenediamine (PPD) serves as an effective screening agent for hair dye contact allergy.
    • PPD is not a reliable marker for predicting sensitivity to disperse dyes.
    • Late patch test readings are important for diagnosing relevant contact allergies to dyes.