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Visualizing Antigen Specific CD4+ T Cells using MHC Class II Tetramers
15:42

Visualizing Antigen Specific CD4+ T Cells using MHC Class II Tetramers

Published on: March 6, 2009

CD4+ T-cell responses to self-peptide--MHC

Qing Ge1, Ailin Bai, Ching-Hung Shen

  • 1Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

Trends in Immunology
|April 17, 2003
PubMed

Interactions between the T-cell receptor (TCR) and self-peptide-MHC (spMHC) have been hypothesized to modulate T-cell reactivity in the periphery. Recent studies examining CD4+ T-cell responses to spMHC class II describe apparently contradictory findings and arrive at opposite conclusions. One explanation for these seemingly disparate results could be the use of mice that were assumed to be MHC class II null but might express some uncommon MHC class II heterodimers.

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