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Related Experiment Videos

Hemocompatibility of titanium oxide films.

N Huang1, P Yang, Y X Leng

  • 1Institute of Biomaterials and Surface Engineering, School of Materials Sciences and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, China. huangnan@sc.homeway.com.cn

Biomaterials
|April 18, 2003
PubMed
Summary

Titanium-oxide (Ti-O) thin films demonstrate excellent hemocompatibility for biomedical applications. Surface modifications using plasma immersion ion implantation and sputtering significantly improve blood-contact material performance.

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Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Materials Engineering

Background:

  • Hemocompatibility is crucial for biomaterials interacting with blood.
  • Surface modification is a promising strategy to enhance biomaterial hemocompatibility.
  • Titanium-oxide (Ti-O) films are explored for improved hemocompatibility.

Purpose of the Study:

  • To improve the hemocompatibility of Ti-O thin films.
  • To characterize Ti-O films prepared via plasma immersion ion implantation and deposition (PIII&D) and sputtering.
  • To evaluate the hemocompatibility of these Ti-O films through comprehensive in vitro and in vivo testing.

Main Methods:

  • Ti-O thin films were prepared using PIII&D and sputtering.
  • Film characterization included X-ray diffraction, Auger electron spectroscopy, AFM, contact angle, and Hall effect measurements.

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  • Hemocompatibility was assessed via fibrinogen adsorption, in vitro clotting assays, platelet adhesion, and in vivo implantation in dogs.

    • Main Results:

    • Characterization revealed specific structural and surface properties of the Ti-O films.
    • Fibrinogen adsorption was quantified, and AFM visualized its behavior.
    • In vitro and in vivo tests demonstrated excellent hemocompatibility of the Ti-O films, with minimal adverse reactions observed up to 90 days.

    Conclusions:

    • Ti-O thin films exhibit superior hemocompatibility compared to unmodified materials.
    • Lower interface tension and semiconducting properties of Ti-O films contribute to their enhanced hemocompatibility.
    • These findings support the use of Ti-O films in blood-contacting biomedical devices.