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Lung cancer associated with diffuse pulmonary fibrosis: CT-pathologic correlation.
Shuji Sakai1, Minoru Ono, Tetsuo Nishio
1Department of Radiology, Kitakyushu Municipal Medical Center, Japan. ssakai@radiol.med.kyushu-u.ac.jp
Journal of Thoracic Imaging
|April 18, 2003
Summary
Bronchogenic carcinoma in patients with diffuse pulmonary fibrosis presents unique imaging features. Computed tomography (CT) reveals distinct tumor characteristics that correlate with specific growth patterns observed in histologic analysis.
Area of Science:
- Radiology
- Pulmonology
- Oncology
Background:
- Diffuse pulmonary fibrosis is a chronic lung disease.
- Bronchogenic carcinoma can occur in patients with pulmonary fibrosis.
- Understanding the imaging characteristics of lung cancer in this context is crucial.
Purpose of the Study:
- To analyze the computed tomographic (CT) findings of bronchogenic carcinomas in patients with diffuse pulmonary fibrosis.
- To correlate CT findings with histologic features.
- To identify distinct morphologic characteristics of these tumors.
Main Methods:
- Review of CT scans and pathologic specimens from 57 histologically proven bronchogenic carcinomas in 47 patients.
- Comparison of CT findings with histologic data in a subgroup of 29 lesions.
- Analysis of tumor location, margins, and presence of intratumor lucency.
Main Results:
- Most tumors (82%) were peripherally located in honeycomb lung.
- Tumors were typically round or lobulated with sharp margins (50/57).
- Intratumor lucencies, often representing engulfed airspaces, were observed in 13 tumors.
Conclusions:
- Bronchogenic carcinoma associated with diffuse pulmonary fibrosis exhibits distinct CT morphologic characteristics.
- These imaging features correlate with specific patterns of tumor invasion and growth.
- CT is valuable in characterizing lung cancer in patients with diffuse pulmonary fibrosis.