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Warfarin-induced tracheobronchial calcification.

Nisa Thoongsuwan1, Eric J Stern

  • 1Department of Radiology, Harborview Medical Center, University of Washington 98104-2499, USA.

Journal of Thoracic Imaging
|April 18, 2003
PubMed
Summary
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Extensive airway calcification, usually normal in the elderly, can be a rare sign of disease. This case highlights pathologic tracheobronchial calcification linked to long-term warfarin use.

Area of Science:

  • Pulmonary Medicine
  • Radiology
  • Pharmacology

Background:

  • Tracheobronchial calcification is common in the elderly, particularly women, and often a normal radiographic finding.
  • Pathologic airway calcification, though rare, can indicate underlying disease processes.
  • Warfarin is an anticoagulant medication used to prevent blood clots.

Observation:

  • Chest radiographs revealed significant, widespread calcification throughout the tracheobronchial tree.
  • Computed tomography (CT) demonstrated extensive calcification of the airway walls.
  • The calcification extended from the main trachea down to the peripheral lung regions.

Findings:

  • The patient presented with pathologic tracheobronchial calcification.
  • This extensive calcification was associated with prolonged warfarin therapy.

Related Experiment Videos

  • The findings suggest a potential link between long-term warfarin use and abnormal airway calcification.

    • Implications:

    • This case suggests warfarin therapy may be an underrecognized cause of extensive tracheobronchial calcification.
    • Further research is warranted to explore the mechanism and prevalence of warfarin-induced airway calcification.
    • Clinicians should consider long-term warfarin use in the differential diagnosis of diffuse tracheobronchial calcification.