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Updated: Aug 18, 2026

Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
Published on: February 16, 2024
[Gastric MALT lymphoma, a malignancy potentially curable by eradication of Helicobacter pylori]
1Service d'Hépato-Gastroentérologie, Hôpital Henri-Mondor, 94010 Créteil Cedex. jean-charles.delchier@hmn.ap-hop-paris.fr
Abstract:
Gastric MALT lymphoma is the most prevalent low-grade marginal zone lymphoma. It is now well demonstrated that gastric MALT lymphoma is strongly related to Helicobacter pylori infection. Prolonged remission of lymphoma is achieved in more than 50% of patients after Helicobacter pylori eradication. Two factors of tumor response were found: presence of perigastric lymph nodes at endoscopic ultrasonography was related to a failure in 2 out of 3 patients; presence of a translocation t (11; 18) with the fusion of two genes implicated in B lymphocytes apoptosis was related to a failure in most of patients. Further studies are needed to determine the most adapted treatment in non-responding patients. A long-term endoscopic follow-up is recommended due to the increased risk of gastric adenocarcinoma in spite of Helicobacter pylori eradication.
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