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Related Experiment Videos

Ear and hearing problems in Turner's syndrome.

M Hultcrantz1

  • 1Department of Otorhinolaryngology, Karolinska Hospital, Stockholm, Sweden. malou.hultcrantz@ks.se

Acta Oto-Laryngologica
|April 19, 2003
PubMed
Summary

Hearing loss in women with Turner's syndrome (TS) is common and linked to karyotype. Estrogen receptors are present in the human inner ear, suggesting a potential role in hearing, warranting further investigation.

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Area of Science:

  • Otolaryngology
  • Genetics
  • Endocrinology

Background:

  • Turner's syndrome (TS) is a genetic condition affecting females.
  • Hearing impairment is a significant health concern for women with TS.
  • The role of estrogen in hearing in TS is not fully understood.

Purpose of the Study:

  • To assess hearing outcomes in Swedish women with TS.
  • To establish otologic management guidelines for TS patients.
  • To investigate the influence of estrogen on hearing.

Main Methods:

  • Audiometric and karyotype testing in 325 women with TS.
  • Questionnaire survey of 143 women with TS.
  • Immunohistochemical analysis of human and animal inner ear tissues for estrogen receptors.

Main Results:

  • 61% of women with TS experienced otitis media.
  • Sensorineural hearing loss was observed from age 6, progressing with time and related to karyotype.
  • Estrogen receptors were confirmed in the human inner ear and detected in various animal models.

Conclusions:

  • Hearing loss patterns and karyotype can predict hearing issues in TS.
  • Estrogen may influence hearing loss in TS, requiring additional research.

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