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Updated: Sep 26, 2026
Covalent Attachment of Single Molecules for AFM-based Force Spectroscopy
Published on: March 16, 2020
Direct force measurements between adlayers consisting of poly(amidoamine) dendrimers with primary amino groups or
Kenichi Sakai1, Saiki Sadayama, Tomokazu Yoshimura
1Department of Applied Chemistry and Institute of Colloid and Interface Science, Science University of Tokyo, Kagurazaka, Shinjuku-ku, Tokyo, 162-8601, Japan.
Abstract:
Adsorption of poly(amidoamine) generation 3 (PAMAM G3) dendrimer with surface amino groups or PAMAM G0 dendrimer with quaternary ammonium groups (C8qbG0) onto glass has been studied by colloidal probe atomic force microscopy. The adlayer-adlayer interactions for these adsorbates are quite different despite the fact that they are almost equal in the hydrodynamic radius. In aqueous PAMAM G3 dendrimer solutions the electrostatic repulsion is predominant. The conformation of the adsorbed layer is flat and the protrusion of the individual dendrimers is negligible. On the other hand, C8qbG0 behaves as a surfactant and the layered structure of C8qbG0 is expected to be a patchy bilayer. Dispersion stability of silica suspensions with the adsorption of these dendrimers can be correlated with the force data obtained.
