Related Experiment Video
Updated: Sep 26, 2026
Comparing the Frequency Effect Between the Lexical Decision and Naming Tasks in Chinese
Published on: April 1, 2016
Implementations of clinical functional magnetic resonance imaging using character-based paradigms for the prediction
Ho-Ling Liu1, Chien-Te Wu, Jian-Chuan Chen
1Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Taiwan. hlaliu@mail.cgu.edu.tw
Purpose:
Recently, functional MRI (fMRI) using word generation (WG) tasks has been shown to be effective for mapping the Chinese language-related brain areas. In clinical applications, however, patients' performance cannot be easily monitored during WG tasks. In this study, we evaluated the feasibility of a word choice (WC) paradigm in the clinical setting and compared the results with those from WG tasks.
Method:
Intrasubject comparisons of fMRI with both WG and WC paradigms were performed on six normal human subjects and two tumor patients. Subject responses in the WC paradigm, based on semantic judgments, were recorded. Activation strength, extent, and laterality were evaluated and compared.
Results:
Our results showed that fMRI with the WC paradigm evoked weaker neuronal activation than that with the WG paradigm in Chinese language-related brain areas. It was sufficient to reveal language laterality for clinical use, however. In addition, it resulted in less nonlanguage-specific brain activation.
Conclusion:
Results from the patient data demonstrated strong evidence for the necessity of incorporating response monitoring during fMRI studies, which suggested that fMRI with the WC paradigm is more appropriate to be implemented for the prediction of Chinese language dominance in clinical environments.
