EGF-dependent and independent activation of MAP kinase during Drosophila oogenesis

Receptor tyrosine kinase (RTK) signaling is involved in multiple cell fate determination during Drosophila oogenesis. To address the problem of signaling specificity, we sought to systematically document the expression pattern of activated MAP kinase, the downstream effector of RTK signaling. We show that MAP kinase is activated in some of the cell types in which Drosophila EGF receptor signaling is known to function. MAP kinase activation is also associated with many cell migration events. Finally, MAP kinase is activated by heat stress without altering follicle cell fates. The implications of these findings are discussed.