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[Breast carcinoma in the elderly].

C Amodeo1, P Caglià, L Gandolfo

  • 1Dipartimento Scienze Chirurgiche, Trapianti e Tecnologie Avanzate, Università degli Studi di Catania.

Annali Italiani Di Chirurgia
|April 23, 2003
PubMed
Summary

Surgery is a viable treatment for elderly women with breast cancer, even those with comorbidities. This study shows surgical outcomes are favorable in patients over 65, challenging contraindications.

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Area of Science:

  • Oncology
  • Geriatric Medicine
  • Surgical Oncology

Context:

  • Breast cancer is a leading cause of cancer death in women, with a significant proportion of diagnoses occurring in individuals over 65.
  • Elderly patients often present with comorbidities, raising concerns about surgical candidacy and outcomes.
  • Treatment strategies for breast cancer in older adults require careful consideration of tumor characteristics and patient health.

Purpose:

  • To evaluate the safety and efficacy of surgical interventions for breast cancer in patients aged 65 and older.
  • To assess the impact of tumor stage and patient comorbidities on treatment outcomes.
  • To determine the role of surgery as a primary treatment modality in elderly breast cancer patients.

Summary:

  • A study of 150 elderly breast cancer patients (≥65 years) undergoing surgery demonstrated varying treatment approaches based on tumor size and stage.

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  • T1/T2 (<2 cm) tumors were treated with quadrantectomy and radiotherapy, while larger T2 (>2 cm) and T3 tumors underwent mastectomy.
  • T4 tumors received neoadjuvant chemotherapy prior to surgery. The mean follow-up was 48 months, with a 28.6% progression rate and an 18.6% five-year mortality rate.

    • Impact:

    • Surgical treatment is effective for breast cancer in elderly women, with acceptable progression and mortality rates.
    • Comorbidities should not be an absolute contraindication for surgery in this demographic.
    • Findings support the continued use of surgery as a cornerstone treatment for breast cancer in the geriatric population.