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Poly(alkylcyanoacrylates) as biodegradable materials for biomedical applications
Christine Vauthier1, Catherine Dubernet, Elias Fattal
1Laboratoire de Physico-chimie, Pharmacotechnie et Biopharmacie, UMR CNRS 8612, Université de Paris XI, 5 Rue Jean Baptiste Clément, 92296 Cedex, Chatenay-Malabry, France. christine.vauthier@cep.u-psud.fr
Advanced Drug Delivery Reviews
|April 23, 2003
Summary
Poly(alkylcyanoacrylates) (PACAs) show promise as biomedical materials, particularly as nanoparticles for drug delivery. This review covers their preparation, properties, and therapeutic applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Nanotechnology
Background:
- Poly(alkylcyanoacrylates) (PACAs) are versatile polymers with established uses in medicine.
- Their unique properties make them suitable for advanced biomedical applications.
Purpose of the Study:
- To review the polymerization of PACAs and their initial applications.
- To extensively discuss PACA nanoparticles for drug delivery, including preparation, properties, and therapeutic uses.
Main Methods:
- Review of existing literature on PACA polymerization and applications.
- Detailed examination of PACA nanoparticle preparation techniques.
- Analysis of studies on nanoparticle degradation, biodistribution, toxicity, and cytotoxicity.
Main Results:
- PACAs are effective as skin adhesives, surgical glues, and embolic agents.
- PACA nanoparticles can be prepared using various methods for controlled drug release.
- Biodegradation, distribution, and toxicity profiles of PACA nanoparticles are discussed.
Conclusions:
- PACAs are a significant class of biomedical materials with diverse applications.
- PACA nanoparticles represent a promising platform for targeted drug delivery across various therapeutic areas.