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Updated: Aug 10, 2026

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
Published on: May 27, 2011
Cutting edge: conventional CD8 alpha+ dendritic cells are preferentially involved in CTL priming after footpad
Christopher M Smith1, Gabrielle T Belz, Nicholas S Wilson
1Cooperative Research Center for Vaccine Technology, University of Melbourne, Victoria, Australia.
Abstract:
CTL play a major role in immunity to HSV type 1, but little is known about the priming process. In this study, we have examined the class I-restricted presentation of an immunodominant determinant from HSV-1 glycoprotein B after footpad infection. We have found that the only cell types capable of presenting this determinant in draining popliteal lymph nodes within the first 3 days after infection are the CD11c(+)CD8alpha(+)CD45RA(-) dendritic cells. Given that such class I-restricted presentation is essential for CTL priming, this implies that these conventional CD8alpha(+) dendritic cells are the key subset involved in CTL immunity to this virus.
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