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Intrathecal methotrexate-induced acute cerebellar syndrome
B Ferhanoglu1, S Ongören, C M Ar
1Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. bferhan@superonline.com
Annals of Hematology
|April 23, 2003
Abstract:
Intrathecal application of chemotherapeutics has been the mainstay of central nervous system prophylaxis in acute lymphoblastic leukemia treatment. We describe a patient who developed acute cerebellar syndrome after prophylactic intrathecal methotrexate administration and recovered spontaneously. To our knowledge, this is the first case of methotrexate-related acute cerebellar syndrome.