Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Street conversations with Henry Kunkel.

K B Elkon1

  • 1Division of Rheumatology and Department of Immunology, University of Washington, Seattle, Washington 98195, USA. elkon@u.washington.edu

Lupus
|April 24, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ribosomal P antibody: 30 years on the road.

Lupus·2017
Same author

Anti-platelet antibodies associated with the Canale-Smith syndrome bind to the same platelet glycoprotein complexes as those of idiopathic thrombocytopenic purpura patients.

Clinical and experimental immunology·2002
Same author

TNF-alpha -dependent maturation of local dendritic cells is critical for activating the adaptive immune response to virus infection.

Proceedings of the National Academy of Sciences of the United States of America·2001
Same author

The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis.

Blood·2001
Same author

Variation in adenovirus transgene expression between BALB/c and C57BL/6 mice is associated with differences in interleukin-12 and gamma interferon production and NK cell activation.

Journal of virology·2001
Same author

Growth regulation of activated lymphocytes: defects in homeostasis lead to autoimmunity and/or lymphoma.

Reviews in immunogenetics·2001
Same journal

Association of systemic lupus erythematosus with 90-day readmission following heart failure hospitalization: A national readmission database (NRD) analysis, 2016-2017.

Lupus·2026
Same journal

Association of GPX4 rs713041 and rs4807542 polymorphisms and serum GPX4 levels in Chinese patients with systemic lupus erythematosus.

Lupus·2026
Same journal

Giant cell myocarditis in an 18-year-old patient with new-onset systemic lupus erythematosus: A fatal case of rapidly progressing heart failure.

Lupus·2026
Same journal

An evidence-based specialist nursing protocol for children with hypoprothrombinemia-lupus anticoagulant syndrome (HLAS) and its application research.

Lupus·2026
Same journal

T-bet expression in B cell subsets: Association with T peripheral helper cells and clinical activity in systemic lupus erythematosus.

Lupus·2026
Same journal

Autonomic dysfunction in systemic lupus erythematosus and systemic sclerosis.

Lupus·2026
See all related articles

In 1982, lupus research focused on understanding autoantigens. New technologies helped uncover their molecular and functional traits, potentially revealing lupus causes.

Area of Science:

  • Immunology
  • Molecular Biology
  • Autoimmune Diseases

Background:

  • In 1982, lupus research advanced significantly, particularly on York Avenue.
  • Emerging technologies like immunoprecipitation and western blotting enabled detailed characterization of lupus autoantigens.

Discussion:

  • The research explored whether autoantigen characteristics—intracellular location, function, immunochemical structure—held clues to lupus etiology.
  • Questions arose regarding potential cross-reactivity between autoantigens and foreign antigens as a contributing factor.

Key Insights:

  • The study highlights the pivotal role of advanced molecular techniques in dissecting complex autoimmune diseases like lupus.
  • Focus shifted towards understanding the specific properties of autoantigens to unravel disease mechanisms.

Related Experiment Videos

Outlook:

  • Further investigation into autoantigen properties was crucial for understanding lupus pathogenesis.
  • The findings paved the way for future research into targeted lupus therapies based on autoantigen characteristics.