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Related Experiment Videos

Ribosomal P antibody: 30 years on the road.

V T Viana1, L Durcan2, E Bonfa1

  • 11 Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazil.

Lupus
|April 11, 2017
PubMed
Summary
This summary is machine-generated.

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Anti-P antibodies, targeting ribosomal phosphoproteins P0, P1, and P2, are specific biomarkers for systemic lupus erythematosus (SLE). Research suggests their role in neuropsychiatric lupus, though further studies are needed to confirm their pathogenic contribution.

Area of Science:

  • Immunology
  • Rheumatology
  • Neuroscience

Background:

  • Anti-cytoplasmic antibodies target acidic ribosomal phosphoproteins P0, P1, and P2.
  • Anti-P antibodies are specific diagnostic markers for systemic lupus erythematosus (SLE), found in 15-35% of patients.
  • Elevated anti-P antibody frequencies are noted in childhood SLE and associated with neuropsychiatric, renal, and hepatic manifestations.

Purpose of the Study:

  • To review the established role of anti-P antibodies in SLE diagnosis.
  • To explore the association and potential pathogenic role of anti-P antibodies in neuropsychiatric lupus.
  • To highlight the need for further research to clarify the clinical significance of anti-P antibodies.

Main Methods:

  • Review of immunological and clinical studies over 30 years.
Keywords:
Lupusautoantibodiesnephritisneuropsychiatric

Related Experiment Videos

  • Analysis of data on anti-P antibody prevalence in SLE patients.
  • Examination of experimental evidence regarding anti-P antibodies and brain disease.

    • Main Results:

    • Anti-P antibodies are highly specific for SLE, with varying prevalence based on ethnicity and age of onset.
    • Longitudinal studies support an association between anti-P antibodies and neuropsychiatric lupus, but predictive value is debated.
    • Experimental studies indicate potential cross-reactivity with neuronal antigens and a direct pathogenic role in brain dysfunction.

    Conclusions:

    • Anti-P antibodies are valuable diagnostic markers for SLE and potentially for neuropsychiatric lupus subsets.
    • The precise clinical impact and pathophysiological role of anti-P antibodies in SLE, particularly neuropsychiatric manifestations, require further elucidation.