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Updated: Sep 26, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness

Published on: May 3, 2018

[Arterial stiffness, wave reflections and myocardial protection: the REASON project]

Gérard M London1

  • 1Centre Hospitalier F.H. Manhès, Fleury-Mérogis, France. glondon@club-internet.fr

Drugs
|April 24, 2003
PubMed

Insights

The REASON study found that perindopril/indapamide significantly reduced systolic blood pressure (SBP) and pulse pressure (PP) more than atenolol in hypertensive patients. This combination therapy may offer superior cardiovascular risk reduction by targeting key pressure parameters.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Systolic blood pressure (SBP) and pulse pressure (PP) are increasingly recognized as critical cardiovascular risk factors, potentially more so than diastolic blood pressure (DBP).
  • Targeted reduction of SBP and PP through specific antihypertensive treatments is of significant clinical interest.

Purpose of the Study:

  • To compare the efficacy of a very low-dose combination of perindopril and indapamide (Per/Ind) versus atenolol in hypertensive patients.
  • To assess the differential effects of these treatments on SBP, DBP, PP, and left ventricular mass index (LVMI).

Main Methods:

  • The REASON project was a randomized, double-blind study involving 471 hypertensive patients over 12 months.
  • Patients received either very low-dose Per/Ind (2mg/0.625mg) or atenolol (50mg).
  • Measurements included brachial blood pressure and echocardiographic assessment of left ventricular hypertrophy.

Main Results:

  • Both treatments similarly reduced DBP, but Per/Ind achieved significantly greater reductions in SBP (p < 0.001) and PP (p < 0.001) compared to atenolol.
  • Patients with baseline left ventricular hypertrophy showed a significantly greater reduction in LVMI with Per/Ind versus atenolol (p = 0.031).

Conclusions:

  • Very low-dose Per/Ind selectively targets SBP and PP more effectively than atenolol.
  • This selective targeting of SBP and PP by Per/Ind may have important implications for reducing cardiovascular risk.
  • Per/Ind demonstrated a superior effect on reducing left ventricular mass in patients with hypertrophy.

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