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Related Experiment Videos

Correlation between stinging, TEWL and capacitance.

Yanyu Wu1, Xuemin Wang, Yutian Zhou

  • 1College of Medicine, Tong Ji University, Shanghai 200065, PRC.

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [And] International Society for Digital Imaging of Skin (ISDIS) [And] International Society for Skin Imaging (ISSI)
|April 24, 2003
PubMed
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This study found a link between skin stinging and the skin barrier. A modified lactic acid stinging test, measuring transepidermal water loss (TEWL) and capacitance (CAP), is a safer way to assess skin susceptibility.

Area of Science:

  • Dermatology
  • Cosmetic Science
  • Skin Physiology

Background:

  • The lactic acid stinging test (LAST) is commonly used to assess skin sensitivity.
  • Understanding the relationship between skin stinging and skin barrier function is crucial for product safety and efficacy.
  • Existing methods may require refinement for improved safety and accuracy.

Purpose of the Study:

  • To investigate the correlation between skin stinging sensations and objective skin barrier parameters.
  • To develop a safer and more reliable method for the lactic acid stinging test.
  • To evaluate the suitability of a modified stinging test for assessing skin susceptibility in specific populations.

Main Methods:

  • A modified lactic acid stinging test (LAST) using 3% and/or 5% aqueous solutions was employed.

Related Experiment Videos

  • Transepidermal water loss (TEWL) and skin capacitance (CAP) were measured as indicators of skin barrier function.
  • Fifty healthy subjects applied 50 microL of the test material to the nasolabial fold, assessing stinging on a 4-point scale at multiple time points.
  • TEWL and CAP were measured at baseline and 8 minutes post-application.

    • Main Results:

    • A tendency for decreased baseline CAP and increased baseline TEWL was observed, correlating with increased clinical stinging scores (CSS).
    • In the 5% lactic acid test, a negative correlation was found between the changing ratio of TEWL (PTEWL) and the clinical score at 5 minutes (CS5 min).
    • Similarly, a negative correlation was registered between the changing ratio of capacitance (PCAP) and CS5 min.

    Conclusions:

    • The degree of skin stinging is demonstrably related to the integrity of the skin barrier.
    • The modified lactic acid stinging test, utilizing lower concentrations and incorporating TEWL and CAP measurements, offers a safer and effective approach.
    • This refined method is suitable for evaluating skin susceptibility, particularly in the Chinese population.