Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Implant surface roughness affects osteoblast gene expression.

G B Schneider1, H Perinpanayagam, M Clegg

  • 1N402, Dows Institute for Dental Research and the Department of Prosthodontics, University of Iowa College of Dentistry, Iowa City 52242, USA. galen-schneider@uiowa.edu

Journal of Dental Research
|April 24, 2003
PubMed
Summary

Dental implant surface texture influences bone cell activity. Roughened surfaces enhance osteoblast differentiation and mineralization, crucial for osseointegration.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Scintillation light detection in the 6-m drift-length ProtoDUNE Dual Phase liquid argon TPC.

The European physical journal. C, Particles and fields·2022
Same author

An experimental approach to analyze aerosol and splatter formations due to a dental procedure.

Experiments in fluids·2021
Same author

Constraints on Lightly Ionizing Particles from CDMSlite.

Physical review letters·2021
Same author

Light Dark Matter Search with a High-Resolution Athermal Phonon Detector Operated above Ground.

Physical review letters·2021
Same author

Correlated charge noise and relaxation errors in superconducting qubits.

Nature·2021
Same author

Impact of hydraulic retention time on phosphorus removal from wastewater using reactive media.

Water science and technology : a journal of the International Association on Water Pollution Research·2020

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Dental Implantology

Background:

  • Osteoblast differentiation is regulated by the transcription factor Cbfa1.
  • The development of a mineralized phenotype is essential for osseointegration.
  • Implant surface microtopography may influence cellular responses.

Purpose of the Study:

  • To investigate the effect of implant surface microtopography on Cbfa1 and BSPII gene expression.
  • To determine how different surface textures (grooved vs. roughened) impact osteoblast mineralization.

Main Methods:

  • Osteoblasts were cultured on commercially pure titanium (cpTi) discs with 600-grit (grooved) or sandblasted (roughened) surfaces.
  • Mineralization was assessed using Alizarin-Red-S staining.
  • Quantitative analysis of Cbfa1 and BSPII gene expression was performed using Real Time PCR.

Related Experiment Videos

Main Results:

  • Osteoblasts cultured on roughened surfaces exhibited enhanced mineralization compared to those on tissue culture plastic.
  • Cbfa1 gene expression significantly increased on roughened surfaces versus grooved surfaces (P < 0.05).
  • BSPII gene expression increased on rough surfaces in UMR cells but decreased in rat calvarial osteoblasts.

Conclusions:

  • Roughened implant surface microtopographies positively affect osteoblast gene expression and mineralization.
  • Surface characteristics of dental implants play a significant role in osseointegration.
  • Further research into implant surface modifications can optimize dental implant success.