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Interactions of amphiphilic calix[4]arene-based Solid Lipid Nanoparticles with bovine serum albumin
Jérôme Gualbert1, Patrick Shahgaldian, Anthony W Coleman
1Institut de Biologie et Chimie des Protéines, CNRS-UMR 5086, 7 Passage du Vercors, Lyon F69367, France.
International Journal of Pharmaceutics
|April 25, 2003
Abstract:
The interaction of Solid Lipid Nanoparticles (SLN) based on amphiphilic calix[4]arene with one of the major circulatory protein, serum albumin, has been investigated by Photon Correlation Spectroscopy (PCS) and Atomic Force Microscopy (AFM). The carrier systems have shown the ability to interact with bovine serum albumin (BSA), which forms a capping layer up to 17nm in depth. AFM imaging revealed that the SLNs are protected by this layer against flattening on surfaces.