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Multicentre evaluation of a new assay for determination of carbohydrate-deficient transferrin
Markus J Schwarz1, Ingrid Domke, Anders Helander
1Psychiatrische Klinik der Ludwig-Maximilian-Universität, München, Germany.
Aims:
The analytical performance of the new Tina-quant % carbohydrate-deficient transferrin (%CDT) was assessed in a multicentre study on Roche/Hitachi analysers.
Methods:
Intra-assay/total precision studies revealed median coefficients of variation (CVs) of 4.7/7.4% within the sites. Precision between the sites was proven using a serum panel.
Results:
Inter-laboratory CVs from 6.3 to 10.7% were obtained. The results of the participating laboratories compared well with high-performance liquid chromatography-UV technique fulfilling the criteria of a reference method for %CDT determination (slope 1.03, intercept -0.09% CDT, correlation 0.984). Good agreement was also found with the Axis-Shield %CDT microtitre test.
Conclusions:
Data from this study indicate that reliable, well standardized %CDT results are obtained using the new assay.
