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Related Experiment Videos

Mesenteric ischemia affects young adults with predisposition.

Bridget M Sanders1, Michael C Dalsing

  • 1Department of Surgery, Division of Vascular Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Annals of Vascular Surgery
|April 25, 2003
PubMed
Summary

Mesenteric ischemia in young adults is rare and often delayed in diagnosis. This study highlights hypercoagulable states as a potential cause, suggesting screening and anticoagulation for prevention.

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Area of Science:

  • Vascular Surgery
  • Gastroenterology
  • Hematology

Background:

  • Arterial mesenteric ischemia is uncommon in patients aged 18-40.
  • Diagnosis and treatment are often delayed in this demographic.
  • Cocaine use is a known risk factor, but other causes exist.

Observation:

  • A retrospective review identified three young patients with arterial mesenteric ischemia.
  • Identified underlying conditions included protein C deficiency, afibrinogenemia, protein C deficiency, antithrombin III deficiency, and Takayasu's arteritis with elevated ESR.
  • All patients experienced prolonged symptoms before diagnosis via angiography and surgical intervention (arterial bypass with/without bowel resection).

Findings:

  • Three cases of arterial mesenteric ischemia in patients under 40 were identified.

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  • Hypercoagulable states were prevalent in these cases.
  • All patients achieved positive outcomes with surgical treatment and survived.

    • Implications:

    • Mesenteric ischemia in young adults, particularly without a history of cocaine use, necessitates a thorough investigation for underlying hypercoagulable disorders.
    • Early identification of these conditions may lead to timely intervention and improved patient outcomes.
    • Long-term anticoagulation therapy could be considered to prevent recurrent episodes.