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Published on: July 4, 2021
[Cerebral sinus thrombosis and ulcerative colitis: two cases]
Sándor Ilniczky1, Róbert Debreczeni, Tibor Kovács
1Semmelweis Egyetem, Altalános Orvosi Kar, Neurológiai Klinika, H-1083 Budapest, Balassa u. 6.
Insights
Inflammatory bowel diseases increase the risk of blood clots, including rare but serious cerebral sinus thrombosis. This summary discusses two ulcerative colitis cases and the IBD-thrombosis connection.
Area of Science:
- Gastroenterology
- Neurology
- Hematology
Background:
- Inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease, are linked to a higher risk of arterial and venous thrombotic events.
- Cerebral sinus thrombosis is a rare, potentially fatal complication associated with IBD, increasingly recognized with modern imaging.
Purpose of the Study:
- To report two cases of ulcerative colitis associated with cerebral sinus thrombosis that were successfully treated.
- To discuss the established link between IBD and thrombotic complications, including potential causes and therapeutic considerations.
Main Methods:
- Case report presentation of two patients with ulcerative colitis and cerebral sinus thrombosis.
- Review of existing literature on the association between IBD and thrombosis, including suspected etiological factors.
Main Results:
- Two cases of ulcerative colitis complicated by cerebral sinus thrombosis were successfully managed.
- The study highlights the importance of recognizing and managing thrombotic risks in IBD patients.
Conclusions:
- Cerebral sinus thrombosis is an uncommon but significant complication of inflammatory bowel diseases.
- Understanding the connection between IBD and thrombosis is crucial for effective patient management and risk mitigation.
Abstract:
Inflammatory bowel diseases (IBD)--ulcerative colitis and Crohn's disease--are associated with increased risk for thrombotic complications both in the arterial and venous system. Cerebral sinus thrombosis is a rare but potentially fatal consequence of these diseases. Modern imaging methods made this uncommon complication of IBD more frequently recognized. The link between IBDs and thrombosis has been extensively studied. Inherited coagulation disorders (APC resistance, antithrombin III and protein-S deficiency), acquired diseases (antiphospholipid syndrome), and the frequent use of corticosteroids were suspected. Two cases of ulcerative colitis associated with cerebral sinus thrombosis successfully treated are reported. The connection between IBD and thrombotic complications and the therapeutic risks are discussed as well.
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