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Determination of absolute structure of macroviracins by chemical synthesis
Shunya Takahashi1, Moritoshi Hosoya, Hiroyuki Koshino
1RIKEN (The Institute of Physical and Chemical Research), Wako, Saitama 351-0198, Japan. shunyat@postman.riken.go.jp
Organic Letters
|April 26, 2003
Abstract:
The relative and absolute configurations of macroviracins have been established by the stereocontrolled synthesis of methyl ester 2a of the C(22) carboxylic acid, a constitutive fatty acid of macroviracin A (1), and their comparison to a sample 2 derived from the natural product 1. [structure: see text]